Butyricicoccus plays a key role in mediating the antagonism between probiotic and antibiotic on food allergy

Butyricicoccus plays a key role in mediating the antagonism between probiotic and antibiotic on food allergy

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Food allergy is a severe food safety problem worldwide.Probiotics are effective in alleviating food allergy whereas antibiotics may exacerbate allergenic responses, but the knowledge on the interplay between them during food CO-Q10 FIRMI BODY LOTION allergy is limited.In the present study, we investigate the activity of probiotic strain Lactobacillus casei (Lc) and antibiotic cocktail (Abx) on in a food allergy mouse model.

The results showed that Lc relieved allergenic symptom and changed allergen-specific antibodies isotypes.Moreover, Lc upregulated chemokines in the spleen, and promoted Saccharomyces Boulardii regulatory CD103+ DC and IgA-producing B cell proliferation.In contrast, the application of Abx eliminated all these beneficial effects of Lc.

Microbiota analysis revealed that the commensal genus Butyricicoccus was a critical mediator in the process.These results revealed the mechanisms of Lc and Abx interaction on food allergy and provided Butyricicoccus as a potential therapeutic target for food allergy.